Physics Colloquium Wednesday, October 2, MG 1000, 16:30

Physics Colloquium Wednesday, October 2, MG 1000, 16:30

September 20, 2013

Theoretical and computational modeling of biomolecular and multi-cellular systems

Ioan Kosztin
Department of Physics and Astronomy, University of Missouri—Columbia

The quantitative description and understanding of the functioning of biological systems is extremely challenging due to their complexity and the wide range of relevant length and time scales involved. This talk will present two examples of how multiscale theoretical and computational modeling can be used to describe and predict the time evolution of biologically relevant systems, and to shed light on the underlying physical mechanisms. The first example is about molecular and ion transport through channel proteins, and is relevant for molecular biology. The second example deals with the shape-changing transformations during biomolecular relaxation of multi-cellular systems, and is relevant for bioprinting, a novel biofabrication technology.

Work supported in part by NSF [PHY-0957914]. Computer time provided by the University of Missouri Bioinformatics Consortium.

References:
1. Kosztin I, Vunjak-Novakovic G, & Forgacs G (2012) Colloquium: Modeling the dynamics of multicellular systems: Application to tissue engineering. Reviews of Modern Physics 84(4):1791-1805.
2. Forney MW, Janosi L, & Kosztin I (2008) Calculating free-energy profiles in biomolecular systems from fast nonequilibrium processes. Phys Rev E Stat Nonlin Soft Matter Phys 78(5 Pt 1):051913.

Level: Advanced